Apolipoprotein L1, income and early kidney damage

Apolipoprotein L1, income and early kidney damage

BACKGROUND The degree to which genetic or environmental factors are associated with early kidney damage among African Americans (AAs) is unknown. METHODS Among 462 AAs in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study, we examined the cross-sectional association between apolipoprotein L1 (APOL1) risk variants and income with: 1) mildly reduced eGFR (<75 mL...

Apolipoprotein l1 and the genetic basis for racial disparity in chronic kidney disease.

Persons of African ancestry living in the United States carry a disproportionate burden of chronic kidney disease (CKD). Compared with Americans of European ancestry, African Americans have an approximately fourfold greater life time risk of ESRD and, on average, require initiation of renal replacement therapy at a younger age. This group also has a unique risk of HIV-associated nephropathy (HI...

DNA Damage and L1 Retrotransposition

Barbara McClintock was the first to suggest that transposons are a source of genome instability and that genotoxic stress assisted in their mobilization. The generation of double-stranded DNA breaks (DSBs) is a severe form of genotoxic stress that threatens the integrity of the genome, activates cell cycle checkpoints, and, in some cases, causes cell death. Applying McClintock's stress hypothes...

Peroxisomes and Kidney Damage

Apolipoprotein L1-associated nephropathy and the future of renal diagnostics.

Apolipoprotein L1 (APOL1)-associated nephropathies comprise a spectrum of related nondiabetic kidney diseases strongly associated with theG1 andG2 coding risk variants in populations with recent African ancestry.1 The spectrum is extremely heterogeneous, ranging from nephrotic syndrome with collapsing glomerulopathy in patients with HIV-associated nephropathy2 to slowly progressive renal failur...